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KMID : 0980720160350010018
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Keimyung Medical Journal
2016 Volume.35 No. 1 p.18 ~ p.24
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An Intra-procedural Stent Thrombosis in a Prasugrel Resistant Patient Treated with Ticagrelor
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Park Jung-Ho
Hur Seung-Ho
Cho Yun-Kyeong
Park Hyoung-Seob
Yoon Hyuck-Jun
Lee Sang-Hoon
Kim Hyung-Seop
Nam Chang-Wook
Han Seong-Wook
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Abstract
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Stent thromboses due to multifactorial causes including hypercoagulable conditions and high on treatment platelet reactivity (HTPR), which means a low response to anti-platelet therapy, especially clopidogrel. Prasugrel is a third generation thienopyridine and inactive pro-drug requiring metabolic activation in vivo, which improves the rate of HTPR with clopidogrel. This drug is mostly effective, with a potent, fast, and consistent anti-platelet action, but rare cases of inadequate platelet inhibition with prasugrel have been reported. Here we describe the case of a 47-year-old man who presented with a recurrent acute myocardial infarction and ST during an intravascular ultrasound pullback and was resistant to prasugrel, was successfully treated with ticagrelor.
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KEYWORD
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Prasugrel resistance, Stent thrombosis, Ticagrelor
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